After four acclaimed seasons, Resident Alien is coming to an end on SYFY and USA Network, and the cast and creators behind the series have shared their thoughts with us at San Diego Comic-Con 2025. Based on Peter Hogan and Steve Parkhouse’s graphic novel of the same name, the sci-fi comedy series has followed the misadventures of the titular extraterrestrial as he crash-lands in Patience, Colorado and attempt to disguise himself as local doctor Harry Vanderspeigle. Befriending his head nurse, Asta, Harry begins developing a compassion for humanity and turns to protecting them from other alien races out to destroy the world.

Resident Alien season 4 has seen Harry, Asta and D’Arcy shocked by the revelation that a Mantid, initially disguising itself as Harry, is on Earth and killing various people and animals in the Patience area. Meanwhile, the trio are also at work trying to finally put a stop to the Greys’ efforts to reclaim Kate’s baby and give up their designs on Earth. With just a few episodes remaining, it was revealed that Resident Alien had been cancelled by USA and SYFY, bringing it to an end with the season 4 finale.

In honor of the show’s appearance at San Diego Comic-Con 2025, ScreenRant hosted Chris Sheridan, Alan Tudyk, Sara Tomko, Alice Wetterlund and Corey Reynolds in our suite to discuss Resident Alien season 4. The group shared their reactions to the cancellation news, including why they weren’t all that surprised by the network’s decision, as well as the biggest lessons they’ve learned from their time on the sci-fi comedy hit, and what advice they’d give to their characters back in the pilot if they were able to go back in time.

Resident Alien’s Cancellation “Wasn’t Brand-New News” For The Show’s Team

While announcements of renewals and cancellations are generally the case going into a show’s final few episodes of a season, Resident Alien’s axing came as something of a surprise to fans given it was just before the show’s panel at SDCC 2025. However, for Sheridan and his cast, not only was it not a surprise, it’s something they’ve seen coming for a few years now, just waiting for the eventual decision by the network. As such, the creator/showrunner sought to make sure fans weren’t left hanging.

“A year ago, when we started the season, I was pretty sure that this is how it would go down,” Sheridan said. “So, in trying to figure out what we were doing creatively for season 4, I made a decision, back then, to finish telling the story. I didn’t want to end up in a situation where we had cliffhangers, and it was left untold, and then we got canceled after that. So, we sort of took it upon ourselves to end it our own way.”

[We knew] that you never know, something else could happen, but we were prepared for this, certainly.

For Tudyk and Reynolds, however, they both had their own humorous takes on why Resident Alien was cancelled, with the former chuckling as he expressed, “I saw it coming from the financial collapse of 2007”. The Sheriff Mike actor agreed with his Emmy-nominated co-star “that’s when it began”, humorously saying one could “trace the roots back” from SYFY and USA Network’s decision to “after the big bailout”.

Tomko expounded on Sheridan’s feelings about how it was “quite surreal” to work on every season of Resident Alien as she and her co-stars were consistently told “They might cancel it”, only for the show to keep running. The Asta actor likened it to the situation in The Boy Who Cried Wolf, questioning if the sci-fi comedy was “ever going to end”, only for them all to agree “We just want to end on our terms” and get it to a place where “it feels good for us and for the fans”.

“So to finally have that phone call,” Tomko recalled, “Chris said, he called us individually — it felt very surreal. I almost feel like I’m not quite sure that I’ll process it until January, when we’re not shooting.”

Reynolds, Tudyk and Wetterlund all turned to joking about Tomko’s analogy, acknowledging there “was definitely something different about this time when the boy cried ‘wolf'”, as this time, they all heard the wolf coming. “And we laughed, and he was like, ‘No, I’m super serious you guys. This wolf is whooping my a–. I need some help over here’,” Reynolds said with a chuckle. “We were like, ‘This guy.’ ”

The Show Taught Them All To Flip The Script On Their Normal Characters

Having played their characters in, and lived in the wacky world of, Resident Alien for nearly five years, the group all acknowledge they will be taking away some big lessons from their time going into future projects. For starters, Tudyk and Reynolds both joke they “have to reel it back in a little bit” with their future roles, with the former admitting “I might go to 11 now” given he’s been living “in the reality of an alien” for long enough that “anything can be justified” with his acting.

“So, any behavior I exhibit, no matter how wild it is, can be justified by who I am,” Tudyk explained. “And in the story itself, the world was very strong that way. It was rooted, and I couldn’t break out of it, and it was amazing for that. So, probably now, going back into more pedestrian-type jobs, I’m going to need to bring the spectrum [of what I do and] funnel it down.”

Reynolds also explained there’s a likelihood that he’ll have to pull back on improvising on other sets the way he did on the sci-fi comedy, recalling conversations with Resident Alien’s script supervisors in which they had to remind the star “we’d like you to stick to the script” after going off on some unexpected tangents while playing Sheriff Mike.

“[They’d come] over to me and say, ‘The line is, ‘I need you in my office at nine o’clock.”,” Reynolds shared. “And [I would say], ‘What did I say?’ And them saying, ‘You said, ‘Hey, what are you doing after work? Do you want to maybe go grab a beer and maybe go by a titty bar? Or do you want to maybe go to Universal Studios and ride some rollercoasters? Because I got a bunch of stuff I got to do, I got like $20 in my pocket.’ That’s what I’m going to have to get used to is toning it down, coming back into the realm of pulling back in. [Chuckles]”

For Wetterlund, on the other hand, she actually found Resident Alien “demanded more” from her on the side of drama, having previously starred in the “similar-type” TBS series People of Earth, albeit not requiring as much drama as comedy, for which she has “always felt extremely confident as a comedic performer”. Admitting to having “a lot less confidence” when she started playing D’Arcy, she praised the experience with the role, her co-stars, particularly “feeding off [Sara’s] energy” and the directors of the show helped her “learn so much”.

I have a lot more confidence in myself as an actor because of this experience. And I’m really proud of the work that we did.

Tomko shared a similar outlook on her time on Resident Alien with all of her co-stars, feeling Asta has let her “play the straight man” and “do a lot of the drama versus the comedy” throughout the show’s run, but that after four seasons, “she’s starting to finally make jokes and have a laugh”. The comedy of the show, particularly Tudyk’s outrageous work as Harry, even led Tomko to attend a clown class, which she just recently graduated, and has given her confidence “to stand out a little bit more” in future productions.

“[I can] try things and just not worry so much about it,” Tomko expressed. “I think I was a little bit like Asta in that way, where I was always a little [bit of a] people-pleaser, wanting to make everybody happy. And now it’s more about just what’s right for the character [and] what’s right for the moment. So I’m going to tone it up.”

Sheridan, having previously garnered five Emmy nominations during his tenure on Family Guy, has spent the past decade “full-time” working on Resident Alien, and while he hopes to be “lucky enough to do this again” and create/showrun another property, the creator will “search for a cast that is near as good as this one” and pray to “get a group that’s nearly as talented” as his cast and creative team. He praised everyone involved as being “so incredibly professional”, not having “a bad one in the bunch” and for “giving you options” to work with.

They add things you didn’t expect to happen. They add physicality you didn’t expect to happen. They all get along. The chemistry is incredible between them. You never get that.

The Cast Have A Few Plot-Related Points Of Advice For Their Characters

As they gear up to say goodbye to the show, the group were all asked what advice they would give their Resident Alien characters if they could travel back in time and talk to them about the pilot. Tudyk, for starters, had more of an acting assurance for himself, joking that he would tell himself not to take “a clowning class between seasons 1 and 2”, even if he was tempted, as he recalls watching himself in season 2 and feeling he got “a little out of control” with Harry’s performance there.

Tomko similarly found she would give herself some creative advice, telling her younger self to “have a good time the whole time” since they would get four seasons out of Resident Alien. “When your job is on the line every season, and you’re not sure, there’s a little fear undercurrent there,” Tomko expressed. “And even though we did have so much fun, I’m sure there were days that I probably let that get to my head. So I’d love to just be like, ‘Hey girl, you’ve got seven years ahead of you. Four seasons. Go for it.'”